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CAS No.: 1192491-61-4

阿维巴坦钠 Catalog No. CSN17540

Synonyms: NXL-104;Avibactam (sodium salt);AVE-1330A

Avibactam Sodium is a synthetic non-β-lactam, covalent, slowly reversible β-lactamase inhibitor.

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生物活性

描述Avibactam (Sodium) is a β-lactamase inhibitor that is in clinical development, combined with β-lactam partners, for the treatment of bacterial infections comprising gram-negative organisms^[3]. Ceftaroline + avibactam (NXL104) is a novel inhibitor combination active against Enterobacteriaceae with class A and C β-lactamases^[4]. Avibactam expands ceftazidime's spectrum of activity to include many ceftazidime- and carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa. Early clinical data indicate that ceftazidime-avibactam is effective and well tolerated in patients with complicated urinary tract infections (cUTIs) and complicated intraabdominal infections (cIAI). In a phase II trial of patients with cUTIs, ceftazidime-avibactam produced similar rates of clinical and microbiologic success compared with imipenem-cilastatin (70.5% and 71.4% microbiologic success rates, respectively)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4816 mL
- 17.4079 mL
- 34.8158 mL
- 5 mM
- 0.6963 mL
- 3.4816 mL
- 6.9632 mL
- 10 mM
- 0.3482 mL
- 1.7408 mL
- 3.4816 mL

技术信息

CAS号

1192491-61-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H10N3NaO6S

运输

蓝冰

分子量

287.23

别名

NXL-104;Avibactam (sodium salt);AVE-1330A;Avibactam;阿维巴坦钠

溶解度

DMSO	56.0 mg/mL (195.0 mM)
Water	55.0 mg/mL (191.5 mM)
Ethanol	Insoluble

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